* When you smoke, nicotine is absorbed into the blood and travels to the brain.
* There are receptors for nicotine in the brain. The nicotine inhaled attaches to these receptors.
* This sends a message to a different part of the brain to release a chemical called dopamine. Dopamine gives a feeling of pleasure. But it only lasts for a short time. The body wants to repeat this feeling.
* It is believed that SmokeLESS works by blocking nicotine from attaching to the receptors.
* SmokeLESS does not contain nicotine. It works in two ways: It targets nicotine receptors in the brain, attaches to them, and blocks nicotine from reaching them. It is believed that SmokeLESS also activates these receptors, causing a reduced release of dopamine (which controls our emotions) compared to nicotine.

1. Nicotine from a cigarette stimulates the release of dopamine - a substance produced by the body which triggers feelings of pleasure.
2. When a smoker quits, the lack of nicotine leads to reduced levels of dopamine, causing feelings of craving and withdrawal
3. SmokeLESS (varenicline) both blocks the nicotine receptors (reducing the addictive power of the drug) and triggers moderate dopamine release to alleviate withdrawal symptoms.

So SmokeLESS is non-addictive but gives smokers the same feel good factor which Nicotine does.
SmokeLESS also diminishes the taste of cigarette and kills the craving for smoke.

SmokeLESS demonstrates
a Novel Combination of Effects
in Smoking Cessation